Publications

Coordinate Papers In Special Issue of Inhalation Toxicology - Available on line

Lippmann, M., Gordon, T., and Chen, L.C., Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: I. Introduction, objectives and experimental plan. Inhalation Toxicology 17:1¨C11 (2005).

Maciejczyk, P., Zhong, M., Li, Q., Xiong, J., Nadziejko, C., and Chen, L.C., Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: II. The design of a concentrated ambient particulate matter exposure system for biometric telemetry monitoring. Inhalation Toxicology 17:1¨C10 (2005).

Hwang, J.S., Nadziejko, C., and Chen, L.C., Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: III. Acute and chronic effects of CAPs on heart rate, heart rate variance, and body temperature. Inhalation Toxicology 17:1¨C9 (2005).

Chen, L.C., and Hwang, J.S., Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: IV. Characterization of acute and chronic effects of ambient air fine particulate matter exposures on heart rate variability.Inhalation Toxicology 17:1¨C8 (2005).

Chen, L.C., and Nadziejko C., Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: V. CAPs exacerbate aortic plaque development in hyperlipidemic mice.Inhalation Toxicology 17:1¨C8 (2005).

Gunnison, A. and Chen, L.C., Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: VI. Measurement of gene expression in heart and lung tissue following exposure. Inhalation Toxicology 17:1¨C9 (2005).

Veronesi, B., Makwana, O., Pooler, M., Weir, L., and Chen, L.C., Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: VII: Degeneration of dopaminergic neurons. Inhalation Toxicology 17:1¨C7 (2005).

Maciejczyk P. and Chen, L.C., Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: VIII. Source-related daily variations in in vitro responses to CAPs. Inhalation Toxicology 17:1¨C11 (2005).

Lippmann M., Gordon T., and Chen, L.C., Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: IX. Integral assessment and human health implications of subchronic exposures of mice to CAPs. Inhalation Toxicology 16:1¨C7 (2005).

Other Papers - Listed alphabetically by first author - available upon request

Chen, L.C., Thurston, G.D., and Schlesinger, R.B. Is airborne acid an important cause of health effects? In: Air Pollution (J. Ayres, R. Richards, R. Maynard, Eds.), Imperial College Press: London (In press).

Chen, L.C. and Thurston, G. World Trade Center cough. Lancet 360:S37-S38 (2002).

Cifuentes, L., Borja-Aburto, V., Gouveia, N., Thurston, G., and Davis, D. Assessing the health benefits of urban air pollution reductions associated with climate change mitigation (2000-2020): Santiago, S‹o Paulo, Mexico City, and New York City. Environmental Health Perspectives 109 Supplement 3:419-425 (2001).

Cifuentes, L., Borja-Aburto, V.H., Gouveia, N., Thurston, G., and Davis, D.L. Climate change. Hidden health benefits of greenhouse gas mitigation. Science 293(5533):1257-1259 (2001).

Cohen, B.S., Heikkinen, M.S.A., Hazi, Y., Gao, H., Peters, P., and Lippmann, M. Field validation of nanofilm acid detectors for assessment of H+ in indoor and outdoor air and measured ambient concentrations of ultrafine acid particles. Health Effects Institute. Report No. 121, September 2004.

Cohen, B.S., Heikkinen, M., and Hazi, Y. Airborne fine and ultrafine particles near the World Trade Center disaster site. Aerosol Science and Technology 38:338-348 (2004).

Cohen, B.S., Li, W., Xiong, J.Q., and Lippmann, M. Detecting H+ in ultrafine ambient aerosol using iron nano-film detectors and scanning probe microscopy. Applied Occupational and Environmental Hygiene 15:80-89 (2000).

Cohen, M.D. Pulmonary immunotoxicology of select metals: Aluminum, arsenic, cadmium, chromium, copper, manganese, nickel, vanadium, and zinc. Journal of Immunotoxicology 1:39-70 (2004).

Cohen, M.D., Sisco, M., Baker, K., Bowser, D., Chen, L.C., and Schlesinger, R.B. Impact of co-exposure to ozone on the carcinogenic potential of inhaled chromium. I. Effects on retention and on extra- and intracellular distribution. Journal of Toxicology and Environmental Health, Part A 66:39-55 (2003).

Cohen, M.D., Sisco, M., Baker, K., Chen, L.C., and Schlesinger, R.B. Effect of inhaled chromium on pulmonary A1AT. Inhalation Toxicology 14:765-771 (2002).

DeLeon, S.F., Thurston, G.D., and Ito, K. Contribution of respiratory disease to non-respiratory mortality associations with air pollution. American Journal of Respiratory and Critical Care Medicine 167:1117-1123 (2003).

Doherty, S.P., Prophete, C., Zelikoff, J., Maciejczyk, P., Salnikow, K., Gould, T., Larson, T., Jaques, P., Koenig, J., Sioutas, C., Lippmann, M., and Cohen M.     Effects of select particulate matter (PM)-associated metals on macrophage (MØ) iron homeostasis. The Toxicologist 78(S1):181-182.

Doherty, S., Prophete, C., Salnikow, K., Lippmann, M., and Cohen, M.D. Use of IRP binding activity analyses to detect changes in iron homeostasis inducible by PM2.5 components. Inhalation Toxicology (In preparation).

Gavett, S.H., Haykal-Coates, N., Highfill, J.W., Ledbetter, A.D., Chen, L.C., Cohen, M.D., Harkema, J.R., Wagner, J.G., and Costa, D.L. World Trade Center fine particulate matter causes respiratory tract hyperresponsiveness in mice. Environmental Health Perspectives 111:981-991 (2003).

Gordon, T. and Reibman, J. Cardiovascular toxicity of inhaled ambient particulate matter. Toxicological Sciences 56:2-4 (2000).

Gwynn, R.C. and Thurston, G.D. The burden of air pollution: Impacts among racial minorities. Environmental Health Perspectives 109 Suppl 4:501-506 (2001).

Hazi, Y., Heikkinen, M.S.A., and Cohen, B.S. Size distribution of acidic sulfate ions in fine ambient particulate matter and assessment of source region effect. Atmospheric Environment 37:5403-5413 (2003).

Huang, Y., Davidson, G., Li, J., Yan, Y., Chen, F., Costa, M., Chen, L.C., and Huang, C. Activation of NF-kB and not AP-1 in cellular response to nickel compounds. Environmental Health Perspectives 110(S5):835-839 (2002).

Ito, K. Associations of particulate matter components with daily mortality and morbidity in Detroit, MI. 143-156 in Revised Analyses of Selected Time-Series Studies, Health Effects Institute Special Report, Health Effects Institute, Cambridge, MA, May 2003.

Ito, K., Thurston, G.D., Nádas, A., and Lippmann, M. Monitor-to-monitor temporal correlation of air pollution in the contiguous U.S. Journal of Exposure Analysis and Environmental Epidemiology 11:21-32 (2001).

Ito, K., Xue, N., and Thurston, G.D. Spatial variation of PM 2.5 chemical species and source-apportioned mass concentrations in New York City. Atmospheric Environment (In press).

Ito, K., Maciejczyk, P., Prophete, C., Li, Q., Gould, T., Larson, T., Jaques, P., Koenig, J., Sioutas, C., Lippmann, M., and Cohen, M.D. Comparative analyses of the metal content of PM2.5 from Seattle, Los Angeles, and New York City. Environmental Science and Technology (In preparation).

Kendall, M., Guntern, J., Lockyer, N.P., Jones, F.H., Hutton, B.M., Lippmann, M., and Tetley, T.D. Urban PM2.5 surface chemistry and interactions with broncho-alveolar lavage fluid (BALF). Inhalation Toxicology 16: 115-129 (2004).

Lall, R., Kendall, M., Ito, K., and Thurston, G.D. Estimation of historical annual PM2.5 exposures for health effects assessment. Atmospheric Environment (In press).

Landrigan, P.J., Lioy, P.J., Thurston, G., Berkowitz, G., Chen, L.C., Chillrud, S.N., Gavett, S.H., Georgopoulos, P.G., Gehy, A.S., Levin, S., Perera, F., Rappaport, S.M., Small, C. and the NIEHS World Trade Center Working Group. Health and environmental consequences of the World Trade Center disaster. Environmental Health Perspectives 112:731-739 (2004).

Lioy, P.J., Weisel, C., Millette, J., Eisenreich, S., Vallero, D., Offenberg, J., Buckley, B., Turpin, B., Zhong, M., Cohen, M.D., Prophete, C., Yang, I., Stiles, R., Chee, G., Johnson, W., Porcja, R., Alimokhtari, S., Hale, R.C., Weschler, C., and Chen, L.C. Characterization of the dust/smoke aerosol that settled east of the World Trade Center (WTC) in lower Manhattan after the collapse of the WTC September 11, 2001. Environmental Health Perspectives 110:703-714 (2002).

Lippmann, M. and Ito, K. Contributions that epidemiological studies can make to the search for a mechanistic basis for the health effects of ultrafine and larger particles. Phil. Trans. R. Soc. Lond. A 358:2787-2797 (2000). Republished as Chapter 16 in: Brown, L.M., Collings, N., Harrison, R.M., Maynard, A.D., and Maynard, R.L. (eds.). Ultrafine Particles in the Atmosphere, London, Imperial College Press, pp. 289-301 (2003).

Lippmann, M. Invited Editorial: Winter air pollution and respiratory function. Occupational and Environmental Medicine 60:81 (2003).

Lippmann, M., Frampton, M., Schwartz, J., Dockery, D., Schlesinger, R.B., Koutrakis, P., Froines, J., et al. The U.S. Environmental Protection Agency particulate matter health effects research centers program: A midcourse report of status, progress, and plans. Environmental Health Perspectives 111:1074-1092 (2003).

Lippmann, M., Ito, K., Nádas, A., and Burnett, R.T. Associations of particulate matter components with daily mortality and morbidity in urban populations. Research Report 95. Health Effects Institute, Cambridge, MA (2000).

Maciejczyk, P.B., Offenberg, J.H., Clemente, J., Blaustein, M., Thurston, G.D., and Chen, L.C. Ambient pollutant concentrations measured by a mobile laboratory in South Bronx, NY. Atmospheric Environment 38: 5283-5294 (2004).

Maciejczyk, P.B., Zeisler, R., Hwang, J-S., and Chen, L.C. Characterization of size-fractionated World Trade Center dust and estimation of relative dust contribution to ambient concentrations. (In press).

McGee, J.K., Chen, L.C., Cohen, M.D., Chee, G., Prophete, C., Haykal-Coates, N., Wasson, S.J., Conner, T.L., Costa, D.L., and Gavett, S.H. Chemical analysis of World Trade Center fine particulate matter for use in toxicological assessment. Environmental Health Perspectives 111:972-980 (2003).

Melikian, A.A., Qu, Q.S., Shore, R., Li, G., Li, H., Jin, X., Cohen, B., Chen, L.C., Li, Y., Yin, S., Mu, R., Zhang, X., and Wang, Y. Personal exposure to different levels of benzene and its relationships to the urinary metabolites S-phenylmercapturic acid and trans,trans-muconic acid. Journal of Chromatography B 778:211-221 (2002).

Nadziejko, C., Chen, L.C., Nádas, A., and Hwang, J.-S. The "fishing license" method for analyzing the time course of effects in repeated measurements. Statistics in Medicine 23: 1399-1411 (2004).

Nadziejko, C., Fang, K., Narciso, S., Zhong, M., Su, W.C., Gordon, T., Nádas, A., and Chen, L.C. Effect of particulate and gaseous pollutants on spontaneous arrhythmias in aged rats. Inhalation Toxicology 16: 373-380 (2004).

Nadziejko, C., Fang, K., Chen, L.C., Gordon, T., and Nádas, A. Quantitative analysis of cardiac data from rats monitored by telemetry: Reducing within- and between-animal variability. Cardiovascular Toxicology 2:237-244 (2002).

Nadziejko, C., Fang, K., Nadziejko, E., Narciso, S.P., Zhong, M., and Chen, L.C. Immediate effects of particulate air pollutants on heart rate and respiratory rate in hypertensive rats. Cardiovascular Toxicology 2:245-252 (2002).

Nadziejko, C., Fang, K., Chen, L.C., Cohen, B., Karpatkin, M., and Nádas, A. Effect of concentrated ambient particulate matter on blood coagulation parameters in rats. Research Report. Health Effects Institute 111:1-23 (2002).

Narciso, S.P., Nadziejko, E., Chen, L.C., Gordon, T., and Nadziejko, C. Adaptation to stress induced by restraining rats and mice in nose-only inhalation holders. Inhalation Toxicology 15:1133-1143 (2003).

Offenberg, J.H., Eisenreich, S.J., Chen, L.C., Cohen, M.D., Chee, G., Prophete, C., Weisel, C., and Lioy, P.J. Persistent organic pollutants in the dusts that settled across lower Manhattan after 11 September 2001. Environmental Science and Technology 37:502-508 (2003).

Payne, J.P., Kemp, S.J., Dewar, C.A., Goldstraw, P., Kendall, M., Chen, L.C., and Tetley, T.D. Airborne particulate matter generated by the World Trade Center (WTC) collapse stimulates cytokine production by human alveolar macrophages (AM) and type II epithelial (TII) cells in vitro. Journal of Occupational and Environmental Medicine 46:420-427 (2004).

Pope, C.A., Burnett, R., Thurston, G.D., Thun, M., Calle, E., Krewski, D., and Godleski, J. Cardiovascular mortality and long-term exposure to particulate air pollution: Epidemiological evidence of general pathophysiological pathways of disease. Circulation 109(1):71-77 (2004).

Pope, C.A. III, Burnett, R.T., Thun, M.J., Calle, E.E., Krewski, D., Ito, K., and Thurston, G.D. Lung cancer, cardiopulmonary mortality and long-term exposure to fine particulate air pollution. Journal of the American Medical Association 287:1132-1141 (2002).

Prophete, C., Maciejczyk, P., Salnikow, K., Gould, T., Larson, T., Koenig, J., Jaques, P., Sioutas, C., Lippmann, M., and Cohen, M. Effects of select PM-associated metals on alveolar macrophage phosphorylated-ERK 1 and 2 and iNOS expression during ongoing alteration in iron homeostasis. Journal of Toxicology and Environmental Health (Submitted).

Qu, Q.S., Cohen, B., Shore, R., Chen, L.C., Li, G., Jin, X., Melikian, A.A., Yin, S., Yan, H., Xu, B., Li, Y., Mu, R., Zhang, X., and Li, K. Benzene exposure measurement in shoe and glue manufacturing: A study to validate biomarkers. Applied Occupational and Environmental Hygiene 18:988-998 (2003).

Qu, Q.S., Shore, R., Li, G., Jin, X., Chen, L.C., Cohen, B., Melikian, A.A., Eastmond, D., Rappaport, S., Li, H., Rupa, D., Waidyanatha, S., Yin, S., Yan, H., Meng, M., Winnik, W., Kwok, E.S.C., Li, Y., Mu, R., Xu, B., Zhang, X., and Li, K. Validation and evaluation of biomarkers in workers exposed to benzene in China. Health Effects Institute Final Report, 2003.

Qu, Q.S., Shore, R., Li, G., Jin, X., Chen, L.C., Cohen, B., Melikian, A.A., Eastmond, D., Rappaport, S.M., Yin, S., Li, H., Waidyanatha, S., Li, Y., Mu, R., Zhang, X., and Li, K. Hematological changes among Chinese workers with a broad range of benzene exposures. American Journal of Industrial Medicine 42:275-285 (2002).

Qu, Q.S., Melikian, A.A., Li, G.L., Shore, R., Chen, L.C., Cohen, B., Yin, S.N., Kagan, M., Li, H., Meng, M., Jin, X., Winnik, W., Li, Y., Mu, R., and Li, K. Validation of biomarkers in humans exposed to benzene: Urine metabolites. American Journal of Industrial Medicine 37:522-531 (2000).

Reibman, J., Hsu, Y., Chen, L.C., Bleck, B., and Gordon, T. Airway epithelial cells release MIP-3a/CCL20 in response to cytokines and ambient particulate matter. American Journal of Respiratory Cell and Molecular Biology 28:648-654 (2003).

Reibman, J., Hsu, Y., Chen, L.C., Kumar, A., Su., W.C., Choy, W., Talbot, A., and Gordon, T. Size fractions of ambient particulate matter induce granulocyte macrophage colony-stimulating factor in human bronchial epithelial cells by mitogen-activated protein kinase pathways. American Journal of Respiratory Cell and Molecular Biology 27:455-462 (2002).

Restrepo, C., Chen, L.C., Thurston, G., Clemente, J., Gorczynski, J., Zhong, M., Blaustein, M., and Zimmerman, R. A comparison of ground-level air quality data with New York State Department of Environmental Conservation Monitoring Stations Data in South Bronx, NY. Atmospheric Environment 38:5295-5304 (2004).

Salnikow, K., Li, X., and Lippmann, M. Effect of nickel and iron co-exposure on human lung cells. Toxicology and Applied Pharmacology 196:258-265 (2004).

Schlesinger, R.B. Properties of ambient PM responsible for human health effects: Coherence between epidemiology and toxicology. Inhalation Toxicology 12 (Suppl. 1):23-25 (2000).

Thurston, G.D. and Chen, L.C. Risk communication in the aftermath of the World Trade Center disaster. American Journal of Industrial Medicine 42(6):543-544 (2002).

Wesselkamper, S.C., Chen, L.C., and Gordon, T. Development of pulmonary tolerance in mice exposed to zinc oxide fumes. Toxicological Sciences 60:144-151 (2001).

Wesselkamper, S.C., Chen, L.C., Kleeberger, S.R., and Gordon, T. Genetic variability in the development of pulmonary tolerance to inhaled pollutants in inbred mice. American Journal of Physiology: Lung Cellular and Molecular Physiology 281:L1200-1209 (2001).

Xiong, J.Q. and Lippmann, M. Development and calibration of a system for semi-continuous monitoring of particle-associated water. Environmental Science and Technology (Submitted).

Yiin, L-M., Millette, J.R., Vette, A., Ilacqua, V., Quan, C., Gorczynski, J., Kendall, M., Chen, L.C., Weisel, C.P., Buckley, B., Yang, I., and Lioy, P. Comparisons of the dust-smoke particulate that settled inside the surrounding buildings and outside on the streets of Southern New York City after the collapse of the World Trade Center, 11 September, 2001. Journal of the Air and Waste Management Association (In press).

Zelikoff, J.T., Chen, L.C., Cohen, M.D., Fang, K., Gordon, T., Li, Y., Nadziejko, C., and Schlesinger, R.B. Effects of inhaled ambient particulate matter on pulmonary anti-microbial immune defense. Inhalation Toxicology 15:131-150 (2003).

Zelikoff, J.T., Schermerhorn, K.R., Fang, K., Cohen, M.D., and Schlesinger, R.B. A role for associated transition metals in the immunotoxicity of inhaled ambient particulate matter. Environmental Health Perspectives 110:871-875 (2002).

Zelikoff, J.T., Chen, L.C., Cohen, M.D., and Schlesinger, R.B. The toxicology of inhaled woodsmoke. Journal of Toxicology and Environmental Health 5:269-282 (2002).

Zelikoff, J.T. Woodsmoke, kerosene heater emissions, and diesel exhaust. In: Pulmonary Immunotoxicology (M.D. Cohen, J.T. Zelikoff, R.B. Schlesinger, Eds.), Klewar Publ., MA. pp. 369-386 (2000).

Zelikoff, J.T., Nadziejko, C., Fang, K., Gordon, T., Premdass, C., and Cohen, M.D. Short-term low-dose inhalation of ambient particulate matter exacerbates ongoing pneumococcal infections in Streptococcus pneumoniae-infected rats. In: Proceedings of the Third Colloquium on Particulate Air Pollution and Human Health (R. Phalen and Y. Bell, Eds.), pp. 8-94-8-101 (1999).