Dr. Herbert Samuels' laboratory is nationally and internationally recognized for its investigation of the mechanism of action of thyroid hormone, and conserved elements of gene regulation by members of the nuclear hormone receptor superfamily. He and his group have defined DNA-protein interactions and protein-protein interactions that regulate control of gene transcription in response to thyroid hormone and retinoic acid. Dr. Samuels' interests extend to delineation of basic molecular mechanisms involved in thyroid hormone resistance syndromes and interaction of the T3-T3 receptor complex with the HIV-1 promoter.