Our current major research areas are:
Platelet physiology: Dr. Simon Karpatkin's work includes the mechanisms of platelet destruction in immune-mediated thrombocytopenia and HIV-associated thrombocytopenia, and the role of thrombin in tumor growth, angiogenesis, and metastasis.
Hypoxic regulation of cellular proliferation: Dr. Lawrence Gardner's research also includes apoptosis, DNA damage and genomic stability and is funded by an NIH Research Development Award.
Human telomeres and telomerase: Dr. Jeffrey Ye's work includes the basic biology of human telomeres and telomerase and their relationship to oncogenesis, as well as potential therapeutic interventions for human malignancy. Dr. Ye's work is also funded by an NIH Research Development Award.
Oncogenes and molecular oncology: Wide range of research programs, from clinical trials using drugs targeted at specific oncogenes to translational research in molecular oncology to basic science approaches in understanding the function of oncogenes.
Molecular biology of polycythemia vera: Molecular analysis of genetic abnormalities in polycythemia vera and related myeloproliferative disorders.
Amyloidosis: Genetic mutations causing amyloidosis.
HTLV-associated disorders: Dr. Dorothea Zucker-Franklin's major interests include the role of HTLV-1 in the pathogenesis of cutaneous T cell malignancies.
Tyrosine kinases: Dr. David Green's studies include the function of receptor tyrosine kinases, with a special focus on FGF and VEGF receptors.
Bone marrow transplantation: Dr. Perry Cook's work includes clinical trials of chemotheapeutic regimens in multiple myeloma, lymphoma, Hodgkin's disease and leukemia.
Angiogenesis: Development of new strategies for anti-angiogenic therapy in cancer, and identification of new angiogenic growth factors.
Drug resistance in acute leukemia: Genetic events leading to drug resistance in acute leukemia.
Lymphoma pathogenesis and lymphoma vaccines: Dr. Tatyana Feldman's work includes clinical trials of anti-idiotype vaccines in follicular lymphoma and studies on lymphoma pathogenesis.
HIV-associated malignancies: Analysis of the changing epidemiology of malignancies in the HIV patient population.
Mechanisms of tumor metastasis: Role of thrombin in tumor metastasis.